Allele and haplotype frequencies in patients with Hematopoietic stemcell transplantation in National Children’s Hospital

HLA (Human Leukocyte Antigen) gene is located on chromosome 6’s short arm, including several loci. genotyping necessary for transplantation, especially in hematopoietic stem cell transplantation. A cross-sectional study to determine the frequency of HLA-A, HLA-B, and HLA-DRB1 alleles 122 patients admitted National Children’s Hospital Hematopoietic transplantation from year between 2010 2020. The patients’ was performed by PCR-SSP method using Micro SSPTM Generic Class I II DNA Typing Tray (One Lambda). results showed that HLA-A locus has 12 which highest are A*11 (24.18%), A*02 (23.36%), A*33 (20.90%), A*24 (14.34%). HLA-B 24 B*15 (24.59%), B*58 (12.30%), B*07 (9.02%), B*46 (8.20%). HLA-C ten C*03 C*07 (22.12%), C*04 (13.52%). 13 DRB1*12 (23.77%), DRB1*03 (11.07%), DRB1*15 (10.25%), DRB1*09 & DRB1*07 There 1984 haplotypes combined 4 loci HLA-C, HLA-DRB1, A*11/B*15/C*08/DRB1*12 (1.21%); A*33/B*58/C*03/DRB1*03 (1.06%); A*11/B*15/C*04/DRB1*12 (0.76%); (0.71%), A*11/B*15/C*03/DRB1*12 (0.71%). provides frequencies genotypes Stem Cell Transplantation. This very important information choosing donors establishing bank.